Combination therapies, particularly varenicline and nicotine replacement therapy (NRT) combined, are the most effective tobacco cessation pharmacotherapies, the largest review to examine the effectiveness and safety of electronic cigarettes (e-cigarettes) and medicines that people use to quit tobacco has found. Varenicline, bupropion, and NRT are recommended as first line treatments to stop smoking by the National Institute for Health and Care Excellence (NICE). E-cigarettes can be used as aids to quit smoking, but currently there are no medically licensed e-cigarettes in the UK. [...]