100 specialists in nicotine science, policy and practice have come together to call on the 182 parties (countries) to the Framework Convention on Tobacco Control to take a more positive stance on tobacco harm reduction.  The letter pushes back against WHO’s misguided and unscientific drive for prohibition or excessive regulation and taxation of vaping products, heated and smokeless tobacco products, and novel oral nicotine products, such as pouches. The letter makes seven main points relevant to FCTC parties and then six recommendations. The letter text must speak for itself.