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Long-term cannabis use is linked to hippocampal atrophy and poorer cognitive function in midlife — known risk factors for dementia.

A large prospective, longitudinal study showed long-term cannabis users had an intelligence quotient (IQ) decline from age 18 to midlife (mean 5.5 IQ points), poorer learning and processing speed compared to childhood, and self-reported memory and attention problems. Long-term cannabis users also showed hippocampal atrophy at midlife (age 45), which combined with mild midlife cognitive deficits, all known risk factors for dementia.