A recent clinical trial investigated the safety of the three most commonly used drugs for quitting smoking: nicotine-replacement therapy, varenicline, and bupropion. The three most commonly used medications for quitting smoking include nicotine-replacement therapy (Nicoderm, Nicorette, Habitrol), varenicline (Champix or Chantix), and bupropion (Zyban). All three drugs may affect cardiac health. Nicotine increases heart rate, blood pressure, and cardiac work.