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Regular smokers who were given cigarettes with low levels of nicotine were found to smoke fewer of them and to have a greater decrease in biomarkers of smoke exposure than those using cigarettes with nicotine content that was gradually reduced in each month of a 5-month study. There was no significant difference in smoke exposure biomarker levels between those who smoked cigarettes with gradually reduced nicotine content and a control group using full nicotine content cigarettes.