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Tobacco and alcohol use, both genetically inheritable behaviors, influence risk for many complex diseases and disorders and are leading causes of mortality. The University of Minnesota was part of a research collaboration that conducted the first study, recently published in Nature Genetics, to identify hundreds of genomic locations associated with addictive behaviors. Researchers found more than 500 genetic variants that affect the use of and addiction to tobacco and alcohol. Until now, only a few of such variants had been identified.