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Vaping most likely represents a less harmful mode of nicotine delivery compared with inhalation of smoke from combustible cigarettes. Although the number and levels of toxicants are lower in aerosol from electronic cigarettes than from tobacco smoke, long term exposure to e-cigarette vapor might cause nicotine dependence and increase the risk of respiratory and cardiovascular health effects. In addition, though the use of e-cigarettes might assist established smokers in quitting smoking, there are widespread concerns [...]