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A recent study raised concerns about the possible toxicity of flavouring additives in e-liquids, identifying several chemical compounds which are considered respiratory irritants. [...] the analysed liquids did not comply with the current EU regulations on e-cigarettes (Tobacco Products Directive).

However, in response to the study renowned tobacco researcher Dr. Konstantinos Farsalinos pointed out that although the flavouring chemicals were identified and quantified, the study did not calculate the potential toxicity of the chemicals in relation to their concentrations.