E‐cigarette aerosols are exceedingly different from conventional tobacco smoke, containing dozens of chemicals not found in cigarette smoke. It is highly likely that chronic use of e‐cigarettes will induce pathologic changes in both the heart and lungs. Here we review human and animal studies published to date and summarize the cardiopulmonary physiologic changes caused by vaping. In terms of cardiac physiology, acute exposure to e‐cigarette aerosols in human subjects led to increased blood pressure and heart rate, similar to traditional cigarettes. [...]