Nicotine Science and Policy
By Harry Shapiro July 10, 2026
Harry’s Blog 132: “Zyn! Went The Strings Of My Heart” (with apologies to Judy Garland)
FDA approval of 20 nicotine pouch products is another step forward for tobacco harm reduction
The FDA in the U.S. has granted marketing authorisation for Zyn nicotine pouch products (five variations on mint plus five other flavours in two different strengths).
In its letter to PMI (who own Zyn manufacturers Swedish Match), the FDA wrote:
Based on our review of your MRTPAs [Modified Risk Tobacco Applications] we determined that the proposed modified risk tobacco products, …as actually used by consumers would significantly reduce harm and the risk of tobacco-related disease to individual tobacco users and benefit the health of the population as a whole, taking into account both users of tobacco products and persons who do not currently use tobacco products. Therefore, we authorize marketing of the tobacco products as modified risk tobacco products with the following modified risk information – “Using ZYN instead of cigarettes puts you at a lower risk of mouth cancer, heart disease, lung cancer, stroke, emphysema and chronic bronchitis”.
July 24, 2026 by substack.com
The Conversation Australia Needed to Have
The National Press Club discussion addressed Australia's illicit tobacco crisis, emphasizing the need to move beyond enforcement to consider broader policy implications. Speakers highlighted the unintended consequences of current strategies, including the role of public policy in fueling the illicit market. Different perspectives were presented, underscoring the need for a more comprehensive national strategy with measurable outcomes. The discussion also explored the intersection of science, regulation, and harm reduction in tobacco control. Ultimately, the event encouraged a reevaluation of Australia's approach to reducing smoking rates while addressing the complexities of the illicit tobacco trade and the need for evidence-based policy decisions.
July 24, 2026 by gfn.tv
GFN.TV Interviews #92 | OVERLOOKED RISK | Smoking’s Toll Among People Who Use Drugs
Smoking among people who use drugs, such as heroin users in England, contributes significantly to premature deaths. Despite this, smoking is often overlooked in drug treatment services. David MacKintosh from the Global State of Tobacco Harm Reduction suggests incorporating safer nicotine options to improve health outcomes and longevity. Drug service providers face challenges in addressing smoking alongside drug issues due to resource constraints. Encouraging harm reduction services to consider smoking cessation could yield positive results. Smoking-related deaths in this population are comparable to drug-related deaths, highlighting the need for comprehensive support and awareness. The Global Forum on Nicotine fosters discussions on harm reduction approaches with a focus on consumer perspectives.
July 24, 2026 by planetofthevapes.co.uk
Smoking Poverty
Smoking is not evenly distributed across society. It is increasingly concentrated among people facing poverty, stress and fewer routes to support — which means tobacco policy cannot be judged only by national averages. If lower-risk alternatives are made harder to access or understand, the burden will fall hardest on the people already most affected by smoking-related harm. A serious strategy must reduce risk without widening inequality.
11.80% of the adult population are current smokers. There are approximately 6.7 million current smokers in United Kingdom 13.60% of men are current smokers but only 10.10% of women.
SOURCE: GSTHR
July 24, 2026 by substack.com
How to spend £8 million
Eight million pounds can buy a lot of public health activity. The harder question is whether it buys better outcomes. Funding should support evidence, transparency and interventions that help smokers move away from combustible tobacco — not campaigns that deepen confusion about lower-risk alternatives. In tobacco policy, spending money is not the same as reducing harm.
11.80% of the adult population are current smokers. There are approximately 6.7 million current smokers in United Kingdom 13.60% of men are current smokers but only 10.10% of women.
SOURCE: GSTHR
July 24, 2026 by clearingtheair.eu
Full switch from smoking to vaping linked to lower heart risk, review finds
Heart risk is not shaped by nicotine alone. A review linking full switching from smoking to vaping with lower cardiovascular risk reinforces the central point of harm reduction: combustion is the major driver of disease. The distinction between dual use and complete switching also matters, because public health gains depend on moving away from cigarettes, not simply adding another product. Risk communication should be clear enough to help smokers understand that difference.
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Blogs
Harry’s Blog 132: “Zyn! Went The Strings Of My Heart” (with apologies to Judy Garland)
FDA approval of 20 nicotine pouch products is another step forward for tobacco harm reduction
The FDA in the U.S. has granted marketing authorisation for Zyn nicotine pouch products (five variations on mint plus five other flavours in two different strengths).
In its letter to PMI (who own Zyn manufacturers Swedish Match), the FDA wrote:
Based on our review of your MRTPAs [Modified Risk Tobacco Applications] we determined that the proposed modified risk tobacco products, …as actually used by consumers would significantly reduce harm and the risk of tobacco-related disease to individual tobacco users and benefit the health of the population as a whole, taking into account both users of tobacco products and persons who do not currently use tobacco products. Therefore, we authorize marketing of the tobacco products as modified risk tobacco products with the following modified risk information – “Using ZYN instead of cigarettes puts you at a lower risk of mouth cancer, heart disease, lung cancer, stroke, emphysema and chronic bronchitis”.
Harry’s Blog 131: Hidden harms
New publications from K•A•C discuss the challenge of smoking in treatment services caring for those who are HIV positive or coping with drug problems.
Smoking rates among those who are HIV positive and those who use drugs (as well as those with mental health problems where there may well be overlap) are anything from two to four times higher than the general adult smoking rates of most developed countries. One study of those receiving opiate substitute treatment recorded a smoking prevalence rate of 85%. Why should this be?
Harry’s blog 130: Follow the science not the money
For the sake of public health, end virtue signalling about THR funding
I arrived into the world of tobacco harm reduction (THR) from drugs and HIV harm reduction in 2015. I was invited into KAC by two valued colleagues from my previous world who were perfectly up front (and have never hidden the fact) that the funding for the organisation came from the Foundation for a Smoke Free World which in turn was funded by Philip Morris International. And the reason that they were prepared to use this money to further the cause of THR was that no other prospective funders for a harm reduction project were interested. Nobody back in the day was excited by the fact that if you could separate nicotine use from combustion the relative risk was massively reduced and the potential health gains enormous.